|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:ApoA-I
|
|
gptkbp:associatedWith
|
gptkb:Tangier_disease
coronary artery disease
familial hypoalphalipoproteinemia
|
|
gptkbp:component
|
gptkb:HDL_particle
high-density lipoprotein particle
|
|
gptkbp:discoveredBy
|
gptkb:Donald_Fredrickson
|
|
gptkbp:encodedBy
|
gptkb:APOA1_gene
|
|
gptkbp:Entrez_Gene_ID
|
335
|
|
gptkbp:enzyme
|
no
|
|
gptkbp:foundIn
|
high-density lipoprotein
|
|
gptkbp:function
|
cholesterol transport
activates lecithin-cholesterol acyltransferase
cholesterol transporter activity
|
|
gptkbp:GOProcess
|
reverse cholesterol transport
|
|
gptkbp:halfLife
|
4-5 days
|
|
gptkbp:HGNC_ID
|
600
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Apolipoprotein A1
|
|
gptkbp:isAllergen
|
no
|
|
gptkbp:locatedOnChromosome
|
chromosome 11q23-q24
|
|
gptkbp:molecularWeight
|
28 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased risk of atherosclerosis
low HDL levels
|
|
gptkbp:OMIM
|
107680
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
2A01
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
glycation
|
|
gptkbp:presentIn
|
gptkb:plasma
|
|
gptkbp:proteinFamily
|
apolipoprotein A family
|
|
gptkbp:RefSeq
|
NM_000039
|
|
gptkbp:relatedTo
|
Apolipoprotein A2
Apolipoprotein A4
Apolipoprotein C3
|
|
gptkbp:sequence
|
243 amino acids
|
|
gptkbp:significance
|
biomarker for cardiovascular disease
|
|
gptkbp:structure
|
amphipathic alpha-helix
|
|
gptkbp:synthesisType
|
liver
intestine
|
|
gptkbp:target
|
gptkb:fibrates
niacin
statins
|
|
gptkbp:UniProtID
|
P02647
|
|
gptkbp:usedIn
|
HDL cholesterol assay
|
|
gptkbp:bfsParent
|
gptkb:APOA1
|
|
gptkbp:bfsLayer
|
7
|