|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:beta-1_adrenoceptor
beta-1 adrenergic receptor
|
|
gptkbp:associatedWith
|
gptkb:arrhythmia
heart failure
hypertension
|
|
gptkbp:discoveredBy
|
gene cloning
|
|
gptkbp:encodes
|
beta-1 adrenergic receptor
|
|
gptkbp:enemyOf
|
gptkb:atenolol
gptkb:metoprolol
gptkb:bisoprolol
gptkb:dobutamine
gptkb:isoproterenol
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000043591
153
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
heart
|
|
gptkbp:fullName
|
gptkb:adrenoceptor_beta_1
|
|
gptkbp:function
|
G protein-coupled receptor activity
adrenergic receptor activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
gptkb:Arg389Gly
gptkb:Ser49Gly
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:286
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ADRB1
|
|
gptkbp:involvedIn
|
regulation of heart rate
regulation of cardiac muscle contraction
|
|
gptkbp:length
|
477 amino acids
|
|
gptkbp:ligand
|
norepinephrine
epinephrine
|
|
gptkbp:locatedOnChromosome
|
10q25.3
|
|
gptkbp:memberOf
|
gptkb:G_protein-coupled_receptor
gptkb:adrenergic_receptor_family
|
|
gptkbp:molecularWeight
|
51 kDa
|
|
gptkbp:OMIM
|
109630
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Adrb1
|
|
gptkbp:pathway
|
gptkb:cAMP_signaling_pathway
adrenergic signaling in cardiomyocytes
|
|
gptkbp:RefSeq
|
gptkb:NM_000684
|
|
gptkbp:regulates
|
adenylate cyclase activity
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
|
|
gptkbp:symbol
|
gptkb:ADRB1
|
|
gptkbp:target
|
beta-blockers
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:UniProtID
|
P08588
|
|
gptkbp:bfsParent
|
gptkb:CHEMBL137
gptkb:CHEMBL402
gptkb:CHEMBL1257
gptkb:CHEMBL692
gptkb:CHEMBL1130
gptkb:CHEMBL1391
|
|
gptkbp:bfsLayer
|
7
|