ATP-binding cassette sub-family A member 1

URI: https://gptkb.org/entity/ATP-binding_cassette_sub-family_A_member_1
GPTKB entity
Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:CERP
HDLCQTL13
ABC-1
ATP-binding cassette transporter 1
Cholesterol efflux regulatory protein
gptkbp:associatedWith gptkb:Tangier_disease
gptkb:familial_HDL_deficiency
gptkbp:biologicalProcess reverse cholesterol transport
ATPase activity
transmembrane transporter activity
cholesterol metabolic process
lipid homeostasis
gptkbp:discoveredBy gptkb:Michael_Hayden
gptkbp:encodedBy gptkb:ABCA1_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000165029
19
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
liver
macrophages
intestine
gptkbp:function lipid transport
cholesterol efflux
phospholipid efflux
gptkbp:gene gptkb:ABCA1
gptkbp:HGNC_ID gptkb:HGNC:29
https://www.w3.org/2000/01/rdf-schema#label ATP-binding cassette sub-family A member 1
gptkbp:length 2261
gptkbp:locatedIn gptkb:human_chromosome_9
gptkbp:location gptkb:plasma_membrane
gptkbp:member gptkb:ATP-binding_cassette_transporter_family
subfamily A
gptkbp:molecularWeight 254 kDa
gptkbp:mutationAssociatedWith gptkb:Tangier_disease
gptkb:familial_HDL_deficiency
gptkbp:OMIM 600046
gptkbp:orthologInMouse Abca1
gptkbp:PDB 7N8A
gptkbp:reviewedBy gptkb:Cell_Metabolism
gptkb:Nature_Genetics
gptkb:Journal_of_Biological_Chemistry
gptkbp:UniProtID gptkb:O95477
gptkbp:bfsParent gptkb:ABCA1
gptkbp:bfsLayer 7