|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
cysteine
histidine
|
|
gptkbp:alsoKnownAs
|
gptkb:Mpro
main protease
|
|
gptkbp:catalyticMechanism
|
cysteine-histidine dyad
|
|
gptkbp:cleavage
|
Leu-Gln↓(Ser,Ala,Gly)
|
|
gptkbp:conservedIn
|
high among coronaviruses
|
|
gptkbp:determines
|
gptkb:cryo-EM
X-ray crystallography
|
|
gptkbp:discoveredIn
|
2003
|
|
gptkbp:EC_number
|
3.4.22.69
|
|
gptkbp:encodedBy
|
gptkb:ORF1ab_polyprotein
|
|
gptkbp:expressedIn
|
infected host cells
|
|
gptkbp:foundIn
|
coronaviruses
|
|
gptkbp:function
|
cleaves viral polyproteins
|
|
gptkbp:gene
|
gptkb:nsp5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
3CL protease
|
|
gptkbp:importantFor
|
major drug target for coronavirus diseases
|
|
gptkbp:inhibitedBy
|
gptkb:nirmatrelvir
gptkb:GC376
gptkb:boceprevir
|
|
gptkbp:inhibitorDevelopment
|
active research area
|
|
gptkbp:inhibitorType
|
peptidomimetic
covalent inhibitor
non-covalent inhibitor
|
|
gptkbp:length
|
306
|
|
gptkbp:locatedOnChromosome
|
gptkb:virus
|
|
gptkbp:molecularWeight
|
33.8 kDa
|
|
gptkbp:orthologIn
|
picornavirus 3C protease
|
|
gptkbp:PDB
|
gptkb:6LU7
7BQY
|
|
gptkbp:potentialTherapeuticTarget
|
yes
|
|
gptkbp:presentIn
|
gptkb:COVID-19
gptkb:MERS-CoV
gptkb:SARS-CoV
gptkb:other_betacoronaviruses
|
|
gptkbp:requires
|
viral replication
virus maturation
|
|
gptkbp:roleInVirus
|
processes viral polyprotein into functional proteins
|
|
gptkbp:structureType
|
gptkb:cysteine_protease
|
|
gptkbp:substrate
|
viral polyprotein
|
|
gptkbp:target
|
antiviral drugs
|
|
gptkbp:targetOfDrug
|
gptkb:SARS
gptkb:COVID-19
gptkb:MERS
|
|
gptkbp:bfsParent
|
gptkb:SARS-CoV-2_virion
|
|
gptkbp:bfsLayer
|
7
|