Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activeSiteResidue |
gptkb:His41
Cys145 |
| gptkbp:alsoKnownAs |
gptkb:3CLpro
|
| gptkbp:determines |
X-ray crystallography
|
| gptkbp:EC_number |
3.4.22.69
|
| gptkbp:encodedBy |
gptkb:ORF1ab_polyprotein
|
| gptkbp:foundIn |
coronaviruses
|
| gptkbp:fullName |
main protease
|
| gptkbp:function |
cleaves viral polyproteins
|
| gptkbp:GO_term |
proteolysis
cysteine-type endopeptidase activity viral process |
| https://www.w3.org/2000/01/rdf-schema#label |
Mpro
|
| gptkbp:inhibitedBy |
gptkb:PF-07321332
gptkb:nirmatrelvir gptkb:GC376 |
| gptkbp:molecularWeight |
33.8 kDa
|
| gptkbp:PDB |
gptkb:6LU7
|
| gptkbp:presentIn |
gptkb:COVID-19
gptkb:MERS-CoV gptkb:SARS-CoV |
| gptkbp:requires |
viral replication
|
| gptkbp:target |
antiviral drug development
|
| gptkbp:bfsParent |
gptkb:SARS-CoV-2_main_protease
|
| gptkbp:bfsLayer |
7
|