Statements (43)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activeSiteResidue |
glutamate
cysteine histidine |
| gptkbp:EC_number |
3.4.22.28
|
| gptkbp:encodedBy |
picornavirus genome
|
| gptkbp:enzymeClassification |
gptkb:cysteine_protease
|
| gptkbp:foundIn |
picornavirus
|
| gptkbp:function |
proteolytic cleavage of viral polyprotein
|
| gptkbp:homologous_to |
gptkb:3CL_protease
|
| https://www.w3.org/2000/01/rdf-schema#label |
3C protease
|
| gptkbp:inhibitedBy |
peptidyl aldehydes
peptidyl chloromethyl ketones peptidyl fluoromethyl ketones |
| gptkbp:presentIn |
rhinovirus
enterovirus aphthovirus cardiovirus cosavirus dicipivirus erbovirus hepatovirus kobuvirus megrivirus mosavirus parechovirus passerivirus rosavirus salivirus sapelovirus seadornavirus senecavirus teschovirus torovirus tremovirus |
| gptkbp:role_in_virus |
modulation of host immune response
processing of viral polyprotein shutoff of host cell transcription |
| gptkbp:structure |
chymotrypsin-like fold
|
| gptkbp:substrate |
Gln-Gly bond
|
| gptkbp:target |
antiviral drug development
|
| gptkbp:bfsParent |
gptkb:hepatitis_A_virus
|
| gptkbp:bfsLayer |
7
|