Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activeSiteResidue |
gptkb:His41
Cys145 |
| gptkbp:alsoKnownAs |
gptkb:3CLpro
main protease |
| gptkbp:cleavage |
Leu-Gln↓(Ser,Ala,Gly)
|
| gptkbp:conservedIn |
high among coronaviruses
|
| gptkbp:EC_number |
3.4.22.69
|
| gptkbp:encodedBy |
coronavirus genome
|
| gptkbp:expressedIn |
infected host cells
|
| gptkbp:foundIn |
gptkb:COVID-19
gptkb:MERS-CoV gptkb:SARS-CoV other coronaviruses |
| gptkbp:function |
gptkb:protease
cleaves viral polyprotein |
| https://www.w3.org/2000/01/rdf-schema#label |
nsp5
|
| gptkbp:inhibitedBy |
gptkb:nirmatrelvir
gptkb:GC376 gptkb:boceprevir |
| gptkbp:locatedOnChromosome |
gptkb:ORF1ab_polyprotein
|
| gptkbp:molecularWeight |
33 kDa
|
| gptkbp:PDB |
gptkb:6LU7
7BQY |
| gptkbp:requires |
coronavirus replication
|
| gptkbp:role |
viral life cycle
|
| gptkbp:structure |
homodimer
|
| gptkbp:target |
antiviral drug development
|
| gptkbp:bfsParent |
gptkb:SARS-CoV-2_virion
|
| gptkbp:bfsLayer |
7
|