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nirmatrelvir
URI:
https://gptkb.org/entity/nirmatrelvir
GPTKB entity
Statements (30)
Predicate
Object
gptkbp:instanceOf
gptkb:chemical_compound
antiviral drug
gptkbp:approvalYear
2021
gptkbp:approvedBy
gptkb:FDA
gptkb:EMA
gptkbp:ATCCode
gptkb:J05AX31
gptkbp:CASNumber
gptkb:2628280-40-8
gptkbp:combines
gptkb:ritonavir
gptkbp:component
gptkb:Paxlovid
gptkbp:developedBy
gptkb:Pfizer
gptkbp:drugClass
protease inhibitor
gptkbp:eliminationHalfLife
6 hours
gptkbp:excretion
urine
gptkbp:hasMolecularFormula
C23H32F3N5O4
https://www.w3.org/2000/01/rdf-schema#label
nirmatrelvir
gptkbp:IUPACName
(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
gptkbp:legalStatus
prescription only
gptkbp:mechanismOfAction
SARS-CoV-2 main protease inhibitor
gptkbp:metabolism
minimal
gptkbp:molecularWeight
499.5 g/mol
gptkbp:pregnancyCategory
Not assigned (US)
gptkbp:routeOfAdministration
oral
gptkbp:sideEffect
diarrhea
hypertension
muscle pain
altered taste
gptkbp:synonym
gptkb:PF-07321332
gptkbp:usedFor
treatment of COVID-19
gptkbp:bfsParent
gptkb:Paxlovid
gptkbp:bfsLayer
5