Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
tumor suppressor |
| gptkbp:alias |
gptkb:von_Hippel-Lindau_protein
gptkb:pVHL |
| gptkbp:discoveredBy |
gptkb:Gregg_L._Semenza
gptkb:Peter_J._Ratcliffe gptkb:William_G._Kaelin_Jr. |
| gptkbp:encodedBy |
gptkb:VHL_gene
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
ubiquitin ligase complex component
regulation of hypoxia-inducible factors |
| https://www.w3.org/2000/01/rdf-schema#label |
VHL tumor suppressor
|
| gptkbp:locatedOnChromosome |
3p25-26
|
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:mutationAssociatedWith |
gptkb:hemangioblastoma
gptkb:pheochromocytoma gptkb:von_Hippel-Lindau_disease renal cell carcinoma |
| gptkbp:NobelPrizeYear |
gptkb:2019_Nobel_Prize_in_Physiology_or_Medicine
|
| gptkbp:partOf |
E3 ubiquitin ligase complex
|
| gptkbp:regulates |
gptkb:HIF1A
HIF2A |
| gptkbp:UniProtID |
P40337
|
| gptkbp:bfsParent |
gptkb:von_Hippel-Lindau_protein_(VHL)
|
| gptkbp:bfsLayer |
7
|