ubiquitin protein ligase E3A

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	gptkb:E6-AP gptkb:E6-associated_protein
gptkbp:associatedWith	gptkb:autism_spectrum_disorder gptkb:Angelman_syndrome gptkb:Prader-Willi_syndrome
gptkbp:biologicalProcess	ubiquitin-dependent protein catabolic process protein binding ubiquitin-protein transferase activity protein catabolic process regulation of synaptic plasticity ligase activity
gptkbp:cellularComponent	cytosol nucleoplasm
gptkbp:EC_number	6.3.2.19
gptkbp:encodedBy	gptkb:UBE3A_gene
gptkbp:expressedIn	gptkb:testis brain
gptkbp:foundIn	gptkb:nucleus gptkb:cytoplasm
gptkbp:function	protein ubiquitination ubiquitin-protein transferase activity
gptkbp:HGNC_ID	12496
gptkbp:interactsWith	gptkb:E6_protein_of_HPV gptkb:p53
gptkbp:locatedIn	gptkb:human_chromosome_15
gptkbp:locatedOnChromosome	gptkb:15q11-q13
gptkbp:molecularWeight	~100 kDa
gptkbp:mutationAssociatedWith	gptkb:Angelman_syndrome
gptkbp:OMIM	601623
gptkbp:orthologInMouse	gptkb:Ube3a
gptkbp:PDB	1C4Z
gptkbp:product	gptkb:UBE3A
gptkbp:UniProtID	gptkb:Q05086
gptkbp:bfsParent	gptkb:Ube3a
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	ubiquitin protein ligase E3A