ubiquitin protein ligase E3A

URI: https://gptkb.org/entity/ubiquitin_protein_ligase_E3A
GPTKB entity
Statements (38)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:E6-AP
gptkb:E6-associated_protein
gptkbp:associatedWith gptkb:autism_spectrum_disorder
gptkb:Angelman_syndrome
gptkb:Prader-Willi_syndrome
gptkbp:biologicalProcess ubiquitin-dependent protein catabolic process
protein binding
ubiquitin-protein transferase activity
protein catabolic process
regulation of synaptic plasticity
ligase activity
gptkbp:cellularComponent cytosol
nucleoplasm
gptkbp:EC_number 6.3.2.19
gptkbp:encodedBy gptkb:UBE3A_gene
gptkbp:expressedIn gptkb:testis
brain
gptkbp:foundIn gptkb:nucleus
gptkb:cytoplasm
gptkbp:function protein ubiquitination
ubiquitin-protein transferase activity
gptkbp:HGNC_ID 12496
https://www.w3.org/2000/01/rdf-schema#label ubiquitin protein ligase E3A
gptkbp:interactsWith gptkb:E6_protein_of_HPV
gptkb:p53
gptkbp:locatedIn gptkb:human_chromosome_15
gptkbp:locatedOnChromosome gptkb:15q11-q13
gptkbp:molecularWeight ~100 kDa
gptkbp:mutationAssociatedWith gptkb:Angelman_syndrome
gptkbp:OMIM 601623
gptkbp:orthologInMouse gptkb:Ube3a
gptkbp:PDB 1C4Z
gptkbp:product gptkb:UBE3A
gptkbp:UniProtID gptkb:Q05086
gptkbp:bfsParent gptkb:Ube3a
gptkbp:bfsLayer 8