Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:A1AT
alpha-1-proteinase inhibitor |
| gptkbp:category |
acute-phase protein
serpin family |
| gptkbp:deficiencyCauses |
gptkb:liver_disease
emphysema |
| gptkbp:discoveredBy |
Laurell and Eriksson
|
| gptkbp:discoveredIn |
1963
|
| gptkbp:encodedBy |
gptkb:SERPINA1_gene
|
| gptkbp:foundIn |
blood plasma
|
| gptkbp:function |
gptkb:serine_protease
|
| https://www.w3.org/2000/01/rdf-schema#label |
alpha-1-antitrypsin
|
| gptkbp:inhibitedBy |
neutrophil elastase
|
| gptkbp:locatedOnChromosome |
14q32.13
|
| gptkbp:medicalUse |
diagnosis of alpha-1-antitrypsin deficiency
|
| gptkbp:molecularWeight |
52 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:Z_allele
S allele |
| gptkbp:OMIM |
107400
|
| gptkbp:presentIn |
extracellular space
lung tissue |
| gptkbp:structure |
gptkb:protein
|
| gptkbp:synthesisType |
liver
|
| gptkbp:treatment |
augmentation therapy
|
| gptkbp:UniProtID |
P01009
|
| gptkbp:bfsParent |
gptkb:trypsin
|
| gptkbp:bfsLayer |
6
|