|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
LACI
TFPI1
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
thrombosis
bleeding disorders
|
|
gptkbp:biologicalProcess
|
blood coagulation
serine-type endopeptidase inhibitor activity
negative regulation of coagulation
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
extracellular region
|
|
gptkbp:discoveredBy
|
Broze GJ Jr.
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodes
|
Tissue factor pathway inhibitor protein
|
|
gptkbp:Entrez_Gene_ID
|
7035
ENSG00000003402
|
|
gptkbp:expressedIn
|
gptkb:plasma
liver
endothelial cells
|
|
gptkbp:fullName
|
Tissue Factor Pathway Inhibitor
|
|
gptkbp:function
|
inhibits tissue factor-induced blood coagulation
regulates extrinsic pathway of coagulation
|
|
gptkbp:GOID
|
GO:0004866
|
|
gptkbp:HGNC_ID
|
gptkb:TFPI
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TFPI gene
|
|
gptkbp:inhibitedBy
|
gptkb:factor_VIIa-tissue_factor_complex
gptkb:factor_Xa
|
|
gptkbp:length
|
9 exons
|
|
gptkbp:locatedOnChromosome
|
2
2q32.1
|
|
gptkbp:medicalUse
|
potential anticoagulant therapy
|
|
gptkbp:mutationAssociatedWith
|
may cause bleeding tendency
may increase risk of thrombosis
|
|
gptkbp:OMIM
|
600514
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
1TFX
|
|
gptkbp:proteinFamily
|
Kunitz-type serine protease inhibitors
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
upregulated by inflammatory cytokines
downregulated in sepsis
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
P10646
|
|
gptkbp:bfsParent
|
gptkb:tissue_factor_pathway_inhibitor
|
|
gptkbp:bfsLayer
|
7
|