|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:EPI
Extrinsic Pathway Inhibitor
Lipoprotein-associated coagulation inhibitor
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
sepsis
coronary artery disease
venous thromboembolism
|
|
gptkbp:biologicalProcess
|
blood coagulation
hemostasis
negative regulation of coagulation
|
|
gptkbp:discoveredBy
|
Broze GJ Jr.
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:domain
|
Kunitz domain
|
|
gptkbp:encodedBy
|
gptkb:TFPI_gene
|
|
gptkbp:Entrez_Gene_ID
|
7035
ENSG00000003436
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:placenta
liver
|
|
gptkbp:foundIn
|
gptkb:plasma
endothelial cells
|
|
gptkbp:fullName
|
Tissue Factor Pathway Inhibitor
|
|
gptkbp:function
|
inhibits tissue factor-induced blood coagulation
regulates extrinsic pathway of coagulation
|
|
gptkbp:gene
|
gptkb:TFPI
|
|
gptkbp:GOID
|
GO:0007596
GO:0050819
|
|
gptkbp:hasIsoform
|
gptkb:TFPI-alpha
gptkb:TFPI-beta
|
|
gptkbp:HGNC_ID
|
11740
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TFPI
|
|
gptkbp:inhibitedBy
|
gptkb:factor_VIIa-tissue_factor_complex
gptkb:factor_Xa
|
|
gptkbp:locatedOnChromosome
|
2q32.1
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:OMIM
|
600514
|
|
gptkbp:orthologInMouse
|
Tfpi
|
|
gptkbp:PDB
|
1TFX
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:proteinFamily
|
gptkb:serine_protease
|
|
gptkbp:RefSeq
|
NM_006527
|
|
gptkbp:regulates
|
regulated by estrogen
upregulated by heparin
|
|
gptkbp:significance
|
deficiency associated with thrombosis risk
|
|
gptkbp:subcellularLocation
|
extracellular space
cell surface
secreted
|
|
gptkbp:UniProtID
|
P10646
|
|
gptkbp:bfsParent
|
gptkb:tissue_factor_pathway_inhibitor
|
|
gptkbp:bfsLayer
|
7
|