corticobasal degeneration

URI: https://gptkb.org/entity/corticobasal_degeneration

GPTKB entity

Predicate	Object
gptkbp:instanceOf	neurodegenerative disease
gptkbp:affects	gptkb:basal_ganglia gptkb:cerebral_cortex brain
gptkbp:alsoKnownAs	gptkb:CBD
gptkbp:associatedWith	tau protein accumulation
gptkbp:cause	unknown
gptkbp:characterizedBy	cognitive impairment progressive movement disorder
gptkbp:diagnosedBy	clinical evaluation MRI PET scan
gptkbp:differentialDiagnosis	gptkb:Alzheimer's_disease gptkb:Parkinson's_disease gptkb:progressive_supranuclear_palsy
gptkbp:duration	6-8 years after onset
gptkbp:firstDescribed	1967
gptkbp:frequency	rare
https://www.w3.org/2000/01/rdf-schema#label	corticobasal degeneration
gptkbp:ICD-10_code	G31.8
gptkbp:MeSH_ID	D020767
gptkbp:mortalityRate	high
gptkbp:namedFor	Rebeiz et al.
gptkbp:notableCase	Case reports in neurology literature
gptkbp:OMIM	600116
gptkbp:onset	usually after age 60
gptkbp:prognosis	poor
gptkbp:progression	gradual
gptkbp:riskFactor	age
gptkbp:symptom	gptkb:dementia tremor dystonia Aphasia myoclonus muscle rigidity speech difficulties
gptkbp:treatment	occupational therapy physical therapy symptomatic
gptkbp:bfsParent	gptkb:Parkinsonism gptkb:The_Cambridge_Centre_for_Parkinson-Plus
gptkbp:bfsLayer	6