progressive supranuclear palsy

GPTKB entity

Predicate	Object
gptkbp:instanceOf	neurodegenerative disease
gptkbp:abbreviation	gptkb:PSP
gptkbp:affects	brain
gptkbp:causedBy	abnormal accumulation of tau protein
gptkbp:characterizedBy	stiffness speech difficulties difficulty with eye movements problems with balance slowed movement swallowing difficulties
gptkbp:diagnosedBy	clinical evaluation MRI
gptkbp:differentialDiagnosis	gptkb:Parkinson's_disease gptkb:corticobasal_degeneration gptkb:multiple_system_atrophy
gptkbp:firstDescribed	gptkb:J.C._Richardson gptkb:Jerzy_Olszewski gptkb:John_Steele 1963
https://www.w3.org/2000/01/rdf-schema#label	progressive supranuclear palsy
gptkbp:ICD-10_code	G23.1
gptkbp:medianSurvival	5 to 10 years after onset
gptkbp:MeSH_ID	D020754
gptkbp:notableCase	gptkb:Dudley_Moore
gptkbp:OMIM	601104
gptkbp:onset	usually after age 60
gptkbp:prevalence	5-7 per 100,000 people
gptkbp:prognosis	progressive and fatal
gptkbp:riskFactor	age
gptkbp:symptom	bradykinesia rigidity apathy cognitive impairment dysphagia frequent falls dysarthria vertical gaze palsy
gptkbp:treatment	supportive care occupational therapy physical therapy speech therapy
gptkbp:bfsParent	gptkb:Abe_Pollin gptkb:Joshua_Logan gptkb:Parkinsonism gptkb:Dudley_Moore gptkb:The_Cambridge_Centre_for_Parkinson-Plus gptkb:Richard_Rainwater gptkb:Richard_E._Rainwater
gptkbp:bfsLayer	6