|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:aggregatesFrom
|
forms amyloid fibrils
|
|
gptkbp:alias
|
gptkb:alpha-synuclein
gptkb:NACP
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
Lewy body dementia
|
|
gptkbp:component
|
Lewy bodies
|
|
gptkbp:degradedBy
|
gptkb:proteasome
autophagy
|
|
gptkbp:discoveredBy
|
gptkb:Spillantini_et_al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
gptkb:SNCA_gene
|
|
gptkbp:expressedIn
|
brain
red blood cells
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
neurotransmitter release
regulation of synaptic vesicle trafficking
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
synuclein alpha
|
|
gptkbp:interactsWith
|
gptkb:tau_protein
gptkb:synphilin-1
gptkb:14-3-3_protein
dopamine
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
neurodegeneration
|
|
gptkbp:length
|
140 amino acids
|
|
gptkbp:locatedIn
|
presynaptic terminals
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q22.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
14 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_Parkinson's_disease
|
|
gptkbp:OMIM
|
163890
|
|
gptkbp:orthologIn
|
mouse alpha-synuclein
rat alpha-synuclein
|
|
gptkbp:pathology
|
major component of Lewy bodies
|
|
gptkbp:PDB
|
1XQ8
|
|
gptkbp:phosphorylates
|
Serine 129
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
nitration
|
|
gptkbp:role
|
protein aggregation
neurotoxicity
mitochondrial dysfunction
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:toxicForm
|
oligomeric alpha-synuclein
|
|
gptkbp:UniProtID
|
gptkb:P37840
|
|
gptkbp:bfsParent
|
gptkb:SNCA_gene
|
|
gptkbp:bfsLayer
|
8
|