small interfering RNA (siRNA)

URI: https://gptkb.org/entity/small_interfering_RNA_(siRNA)
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf RNA molecule
gptkbp:abbreviation gptkb:siRNA
gptkbp:application gptkb:cancer
antiviral therapy
functional genomics
gptkbp:category non-coding RNA
gptkbp:component gptkb:RNA-induced_silencing_complex_(RISC)
gptkbp:discoveredBy gptkb:Andrew_Fire
gptkb:Craig_Mello
gptkbp:discoveredIn 1998
gptkbp:foundIn animals
fungi
plants
gptkbp:function gptkb:RNA_interference
gene silencing
gptkbp:hasApprovedDrug gptkb:Givosiran
Lumasiran
Patisiran
https://www.w3.org/2000/01/rdf-schema#label small interfering RNA (siRNA)
gptkbp:inducedBy post-transcriptional gene silencing
gptkbp:length 20-25 nucleotides
gptkbp:mechanismOfAction induces mRNA degradation
binds to complementary mRNA
gptkbp:origin exogenous or endogenous
gptkbp:relatedTo gptkb:microRNA_(miRNA)
short hairpin RNA (shRNA)
gptkbp:sequenceSpecificity high
gptkbp:structure double-stranded
gptkbp:therapeuticPotential high
gptkbp:usedIn therapeutic applications
gene knockdown experiments
gptkbp:bfsParent gptkb:Leqvio
gptkbp:bfsLayer 6