small interfering RNA (siRNA)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:RNA_molecule
gptkbp:abbreviation	gptkb:siRNA
gptkbp:application	gptkb:cancer antiviral therapy functional genomics
gptkbp:category	gptkb:non-coding_RNA
gptkbp:component	gptkb:RNA-induced_silencing_complex_(RISC)
gptkbp:discoveredBy	gptkb:Andrew_Fire gptkb:Craig_Mello
gptkbp:discoveredIn	1998
gptkbp:foundIn	animals fungi plants
gptkbp:function	gptkb:RNA_interference gene silencing
gptkbp:hasApprovedDrug	gptkb:Givosiran Lumasiran Patisiran
gptkbp:inducedBy	post-transcriptional gene silencing
gptkbp:length	20-25 nucleotides
gptkbp:mechanismOfAction	induces mRNA degradation binds to complementary mRNA
gptkbp:origin	exogenous or endogenous
gptkbp:relatedTo	gptkb:microRNA_(miRNA) short hairpin RNA (shRNA)
gptkbp:sequenceSpecificity	high
gptkbp:structure	double-stranded
gptkbp:therapeuticPotential	high
gptkbp:usedIn	therapeutic applications gene knockdown experiments
gptkbp:bfsParent	gptkb:RNA_(single_helix) gptkb:Nedosiran gptkb:ONPATTRO gptkb:OXLUMO gptkb:Leqvio
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	small interfering RNA (siRNA)