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gptkbp:instanceOf
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biological molecule
non-coding RNA molecule
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gptkbp:abbreviation
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gptkb:miRNA
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gptkbp:biogenesis
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exported to cytoplasm
processed to mature miRNA
processed to precursor miRNA (pre-miRNA)
transcribed as primary miRNA (pri-miRNA)
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gptkbp:component
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gptkb:RNA-induced_silencing_complex_(RISC)
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gptkbp:conservationProgram
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evolutionarily conserved
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gptkbp:database
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gptkb:miRBase
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gptkbp:discoveredBy
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gptkb:Victor_Ambros
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gptkbp:discoveredIn
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1993
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gptkbp:discoveredInOrganism
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gptkb:Caenorhabditis_elegans
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gptkbp:encodedBy
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miRNA genes
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gptkbp:firstIdentifiedAs
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lin-4 RNA
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gptkbp:foundIn
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animals
plants
viruses
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gptkbp:function
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regulation of gene expression
post-transcriptional gene silencing
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https://www.w3.org/2000/01/rdf-schema#label
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microRNA (miRNA)
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gptkbp:length
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about 21-25 nucleotides
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gptkbp:mechanismOfAction
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induces mRNA degradation
inhibits translation
binds to complementary sequences in mRNA
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gptkbp:processor
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gptkb:Drosha_enzyme
gptkb:Dicer_enzyme
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gptkbp:regulates
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protein synthesis
mRNA stability
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gptkbp:relatedTo
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gptkb:siRNA
gptkb:piRNA
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gptkbp:role
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gptkb:cancer
gptkb:disease
apoptosis
cell differentiation
development
immune response
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gptkbp:sequence
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single-stranded
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gptkbp:studiedIn
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gptkb:cardiovascular_disease
cancer research
developmental biology
neurobiology
virology
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gptkbp:therapeuticPotential
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gene therapy
biomarker
drug target
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gptkbp:bfsParent
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gptkb:small_interfering_RNA_(siRNA)
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gptkbp:bfsLayer
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7
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