|
gptkbp:instanceOf
|
gptkb:antibiotic
|
|
gptkbp:chemicalClass
|
ansamycins
|
|
gptkbp:contraindication
|
severe liver disease
|
|
gptkbp:discoveredBy
|
gptkb:Piero_Sensi
Gabriele Maga
Giovanni Arcamone
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:drugInteraction
|
induces cytochrome P450 enzymes
|
|
gptkbp:example
|
gptkb:rifampicin
gptkb:rifaximin
gptkb:rifabutin
rifalazil
rifapentine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
rifamycin antibiotics
|
|
gptkbp:mechanismOfAction
|
inhibits bacterial DNA-dependent RNA polymerase
|
|
gptkbp:origin
|
gptkb:Amycolatopsis_mediterranei
|
|
gptkbp:resistantTo
|
mutation in rpoB gene
|
|
gptkbp:routeOfAdministration
|
oral
topical
intravenous
|
|
gptkbp:sideEffect
|
hepatotoxicity
gastrointestinal upset
orange discoloration of body fluids
|
|
gptkbp:spectrumOfActivity
|
Gram-positive bacteria
some Gram-negative bacteria
|
|
gptkbp:subclassOf
|
antibacterial
|
|
gptkbp:usedFor
|
treatment of tuberculosis
treatment of leprosy
treatment of mycobacterial infections
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
gptkb:rifampicin
|
|
gptkbp:bfsParent
|
gptkb:rifampicin
|
|
gptkbp:bfsLayer
|
5
|