|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PKM1
gptkb:PKM2
gptkb:Pyruvate_kinase_isozymes_M1/M2
|
|
gptkbp:alternativeSplicing
|
produces PKM1 and PKM2 isoforms
|
|
gptkbp:associatedWith
|
cancer metabolism
|
|
gptkbp:cofactor
|
K+
Mg2+
|
|
gptkbp:Entrez_Gene_ID
|
ENSP00000335181
|
|
gptkbp:enzymeCommissionNumber
|
2.7.1.40
|
|
gptkbp:expression_regulation
|
regulated by alternative splicing
|
|
gptkbp:fullName
|
gptkb:Pyruvate_kinase_PKM
|
|
gptkbp:function
|
catalyzes the final step of glycolysis
|
|
gptkbp:gene
|
gptkb:PKM
|
|
gptkbp:Gene_Ontology:_biological_process
|
glycolytic process
|
|
gptkbp:Gene_Ontology:_cellular_component
|
cytosol
|
|
gptkbp:Gene_Ontology:_molecular_function
|
pyruvate kinase activity
|
|
gptkbp:hasIsoform
|
gptkb:PKM1
gptkb:PKM2
|
|
gptkbp:HGNC_ID
|
HGNC:9021
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P14618 (human PKM)
|
|
gptkbp:KEGG_entry
|
hsa:5315
|
|
gptkbp:length
|
531 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
15q23
|
|
gptkbp:molecularWeight
|
58 kDa
|
|
gptkbp:OMIM
|
609937
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
glycolysis
|
|
gptkbp:PDB
|
gptkb:3GR4
gptkb:1T5A
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
acetylation
|
|
gptkbp:product
|
gptkb:ATP
gptkb:pyruvate
|
|
gptkbp:Reactome
|
gptkb:R-HSA-70171
|
|
gptkbp:RefSeq
|
gptkb:NP_002645.3
|
|
gptkbp:reviewedBy
|
yes
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:significance
|
biomarker in cancer
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:substrate
|
gptkb:ADP
phosphoenolpyruvate
|
|
gptkbp:tissue_specificity
|
expressed in most tissues
|
|
gptkbp:UniProt_entry_name
|
KPYM_HUMAN
|
|
gptkbp:UniProtID
|
P14618
|
|
gptkbp:bfsParent
|
gptkb:pyruvate_kinase
|
|
gptkbp:bfsLayer
|
6
|