|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PK1
gptkb:Pyruvate_kinase_isozymes_R/L
gptkb:Pyruvate_kinase_liver_and_red_blood_cell
|
|
gptkbp:associatedWith
|
pyruvate kinase deficiency
|
|
gptkbp:catalyzes
|
ATP + pyruvate = ADP + phosphoenolpyruvate
|
|
gptkbp:cofactor
|
K+
Mg2+
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:PKLR
gptkb:ENSP00000367410
|
|
gptkbp:enzymeCommissionNumber
|
2.7.1.40
|
|
gptkbp:expressedIn
|
high in liver
high in red blood cells
|
|
gptkbp:family
|
gptkb:pyruvate_kinase_family
|
|
gptkbp:function
|
pyruvate kinase activity
|
|
gptkbp:gene
|
gptkb:PKLR
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasIsoform
|
liver isoform
red blood cell isoform
|
|
gptkbp:HGNC_ID
|
9021
|
|
gptkbp:KEGGID
|
gptkb:hsa:5313
|
|
gptkbp:locatedOnChromosome
|
1
1q21
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
62 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:anemia
|
|
gptkbp:OMIM
|
609712
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Pklr
gptkb:rat_Pklr
|
|
gptkbp:pathway
|
glycolysis
|
|
gptkbp:PDB
|
gptkb:2VGB
1A49
3E6E
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
succinylation
|
|
gptkbp:product
|
gptkb:ATP
gptkb:pyruvate
|
|
gptkbp:Reactome
|
gptkb:R-HSA-70263
|
|
gptkbp:RefSeq
|
gptkb:NP_000288.1
|
|
gptkbp:sequence
|
574 amino acids
|
|
gptkbp:substrate
|
gptkb:ADP
phosphoenolpyruvate
|
|
gptkbp:subunit
|
homotetramer
|
|
gptkbp:tissue_specificity
|
liver
erythrocyte
|
|
gptkbp:UniProtID
|
P14618
|
|
gptkbp:bfsParent
|
gptkb:pyruvate_kinase
gptkb:Pyruvate_kinase
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P14618 (human PKLR)
|