proliferating cell nuclear antigen (PCNA)

URI: https://gptkb.org/entity/proliferating_cell_nuclear_antigen_(PCNA)
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alias gptkb:cyclin
gptkb:PCNA
proliferating cell nuclear antigen
gptkbp:alternativeName gptkb:cyclin
gptkbp:associatedWith gptkb:cancer
gptkbp:biologicalProcess DNA clamp
gptkbp:discoveredBy 1987
gptkbp:Entrez_Gene_ID ENSG00000132646
gptkbp:expressedIn proliferating cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function DNA repair
cell cycle regulation
DNA replication
gptkbp:gene gptkb:PCNA
PCNA gene
gptkbp:GO_term GO:0005657
GO:0006260
GO:0030330
gptkbp:HGNC_ID HGNC:8729
https://www.w3.org/2000/01/rdf-schema#label proliferating cell nuclear antigen (PCNA)
gptkbp:interactsWith gptkb:p21
gptkb:FEN1
gptkb:DNA_polymerase_delta
RFC complex
DNA polymerase epsilon
gptkbp:length 261
gptkbp:locatedOnChromosome 20p12.3
gptkbp:location gptkb:nucleus
gptkbp:molecularWeight 29 kDa
gptkbp:orthologIn gptkb:mouse
gptkb:yeast
gptkb:Drosophila_melanogaster
gptkbp:PDB gptkb:1AXC
gptkbp:postTranslationalModification phosphorylation
sumoylation
ubiquitination
gptkbp:RefSeq NM_002592
gptkbp:structure homotrimer
gptkbp:subunit homotrimeric ring
gptkbp:UniProtID P12004
gptkbp:used_as_marker_for cell proliferation
gptkbp:used_in cancer diagnostics
immunohistochemistry
cell cycle studies
gptkbp:bfsParent gptkb:ATAD5
gptkb:NKp44
gptkb:DNA_polymerase_delta
gptkbp:bfsLayer 8