programmed death-ligand 1 (PD-L1)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:CD274 gptkb:B7-H1
gptkbp:binds	gptkb:PD-1
gptkbp:discoveredIn	1999
gptkbp:encodedBy	gptkb:CD274_gene
gptkbp:Entrez_Gene_ID	29126
gptkbp:expressedIn	gptkb:cancer gptkb:placenta liver lymph nodes spleen bone marrow tumor cells antigen-presenting cells various tumors
gptkbp:foundIn	humans other mammals
gptkbp:function	immunotherapy
gptkbp:hasBiomarker	immunotherapy response
https://www.w3.org/2000/01/rdf-schema#label	programmed death-ligand 1 (PD-L1)
gptkbp:inhibitedBy	immune response
gptkbp:involvedIn	negative regulation of immune response T cell exhaustion maternal-fetal tolerance peripheral tolerance
gptkbp:involves	autoimmune diseases cancer immune evasion chronic infections
gptkbp:locatedOnChromosome	gptkb:chromosome_9
gptkbp:modulatedBy	gptkb:interferon_gamma inflammatory cytokines
gptkbp:OMIM	605402
gptkbp:regulates	T cell activity
gptkbp:structure	type I transmembrane protein
gptkbp:target	gptkb:durvalumab gptkb:atezolizumab gptkb:pembrolizumab gptkb:nivolumab gptkb:avelumab immunotherapy checkpoint inhibitors
gptkbp:UniProtID	Q9NZQ7
gptkbp:usedIn	cancer prognosis companion diagnostics patient stratification
gptkbp:bfsParent	gptkb:Durvalumab
gptkbp:bfsLayer	6