programmed cell death protein 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein immunotherapy
gptkbp:abbreviation	gptkb:PD-1
gptkbp:alternativeName	gptkb:CD279 PDCD1 protein
gptkbp:biologicalProcess	immune tolerance T cell exhaustion
gptkbp:discoveredBy	gptkb:Tasuku_Honjo
gptkbp:discoveredIn	1992
gptkbp:Entrez_Gene_ID	5133 ENSG00000188389
gptkbp:expressedIn	gptkb:B_cells gptkb:T_cells dendritic cells monocytes
gptkbp:extracellular_domain	IgV-like domain
gptkbp:foundIn	humans mice other mammals
gptkbp:function	regulates immune response inhibits T cell activity
gptkbp:gene	PDCD1
gptkbp:hasTherapeuticUse	gptkb:cancer immunotherapy autoimmune disease modulation
gptkbp:HGNC_ID	gptkb:HGNC:8765
https://www.w3.org/2000/01/rdf-schema#label	programmed cell death protein 1
gptkbp:intracellular_domain	ITIM motif ITSM motif
gptkbp:ligand	gptkb:PD-L2 PD-L1
gptkbp:locatedOnChromosome	chromosome 2 (human)
gptkbp:molecularWeight	approximately 55 kDa
gptkbp:OMIM	600244
gptkbp:pathway	immune checkpoint pathway PD-1 signaling pathway
gptkbp:PDB	3RRQ
gptkbp:role	autoimmune diseases cancer immune evasion chronic infections
gptkbp:structure	type I transmembrane protein
gptkbp:targetOfDrug	gptkb:camrelizumab gptkb:sintilimab gptkb:tislelizumab gptkb:toripalimab gptkb:pembrolizumab gptkb:cemiplimab gptkb:nivolumab atezolizumab (indirectly via PD-L1)
gptkbp:UniProtID	Q15116
gptkbp:bfsParent	gptkb:Sintilimab
gptkbp:bfsLayer	7