phosphoinositide 3-kinase (PI3K) class IA
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases |
| gptkbp:catalyzes |
phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2) to phosphatidylinositol (3,4,5)-trisphosphate (PIP3)
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes autoimmune diseases |
| gptkbp:encodedBy |
gptkb:PIK3CA_gene
gptkb:PIK3CB_gene gptkb:PIK3CD_gene |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:hasIsoform |
gptkb:PI3Kδ
PI3Kα PI3Kβ |
| https://www.w3.org/2000/01/rdf-schema#label |
phosphoinositide 3-kinase (PI3K) class IA
|
| gptkbp:inhibitedBy |
gptkb:LY294002
gptkb:wortmannin |
| gptkbp:involvedIn |
gptkb:PI3K/AKT_signaling_pathway
|
| gptkbp:locale |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:regulates |
cell proliferation
cell survival metabolism cell growth cell migration |
| gptkbp:subunit |
p110 catalytic subunit
p85 regulatory subunit |
| gptkbp:bfsParent |
gptkb:p110α
|
| gptkbp:bfsLayer |
6
|