phosphoglycerate kinase 1 protein

URI: https://gptkb.org/entity/phosphoglycerate_kinase_1_protein
GPTKB entity
Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:PGK1
cellular phosphoglycerate kinase
gptkbp:associatedWith phosphoglycerate kinase deficiency
gptkbp:cofactor Mg2+
gptkbp:discoveredIn 1950s
gptkbp:encodedBy PGK1 gene
gptkbp:Entrez_Gene_ID 5230
gptkbp:enzymeCommissionNumber EC 2.7.2.3
gptkbp:expressedIn most tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function catalyzes the transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP
https://www.w3.org/2000/01/rdf-schema#label phosphoglycerate kinase 1 protein
gptkbp:interactsWith gptkb:HIF-1α
gptkb:p53
gptkb:VEGF
gptkbp:involvedIn glycolysis
gptkbp:length 417 amino acids
gptkbp:locatedOnChromosome Xq13.3
gptkbp:location gptkb:cytoplasm
gptkbp:molecularWeight 44 kDa
gptkbp:OMIM 300653
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Rattus_norvegicus
gptkbp:PDB gptkb:2XE7
gptkb:1PHP
gptkb:3C39
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:product gptkb:ATP
gptkb:3-phosphoglycerate
gptkbp:regulates regulated by HIF-1
upregulated in hypoxia
gptkbp:roleInCancer involved in chemoresistance
overexpressed in several cancers
promotes tumor growth
gptkbp:significance mutations cause hemolytic anemia
mutations cause myopathy
gptkbp:structure monomer
gptkbp:substrate gptkb:ADP
1,3-bisphosphoglycerate
gptkbp:UniProtID gptkb:P00558
gptkbp:bfsParent gptkb:PGK1
gptkbp:bfsLayer 8