paraneoplastic syndromes

GPTKB entity

Statements (48)
Predicate Object
gptkbp:instanceOf medical condition
gptkbp:affects multiple organ systems
gptkbp:associatedWith gptkb:cancer
gptkbp:canBe cutaneous
life-threatening
hormonal
autoimmune
hematologic
metabolic
neurologic
gptkbp:canOccurBefore cancer diagnosis
gptkbp:cause neurological symptoms
dermatological symptoms
endocrine symptoms
hematological symptoms
musculoskeletal symptoms
rheumatological symptoms
gptkbp:causedBy infection
metastasis
direct tumor invasion
gptkbp:commonIn gptkb:cancer
leukemia
Small Cell Lung Cancer
gptkbp:diagnosedBy laboratory tests
clinical evaluation
imaging studies
gptkbp:example gptkb:dermatomyositis
gptkb:Lambert-Eaton_myasthenic_syndrome
gptkb:hypercalcemia
gptkb:Cushing_syndrome
gptkb:SIADH
gptkb:acanthosis_nigricans
gptkb:migratory_thrombophlebitis
gptkb:paraneoplastic_cerebellar_degeneration
polycythemia
gptkbp:firstDescribed 1940s
https://www.w3.org/2000/01/rdf-schema#label paraneoplastic syndromes
gptkbp:mechanismOfAction cytokine release
ectopic hormone production
immune cross-reactivity
gptkbp:occurredIn gptkb:cancer
gptkbp:occursAfter cancer diagnosis
gptkbp:treatment immunosuppression
symptomatic management
treat underlying cancer
gptkbp:bfsParent gptkb:neuroblastoma
gptkb:SIADH
gptkbp:bfsLayer 6