| 
                                    
                                        gptkbp:instanceOf
                                    
                                 | 
                                
                                    
                                        
                                            gptkb:medical_condition
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:affects
                                    
                                 | 
                                
                                    
                                        
                                            
                                            multiple organ systems
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:associatedWith
                                    
                                 | 
                                
                                    
                                        
                                            gptkb:cancer
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:canBe
                                    
                                 | 
                                
                                    
                                        
                                            
                                            cutaneous
                                        
                                        
                                         
                                    
                                        
                                            
                                            life-threatening
                                        
                                        
                                         
                                    
                                        
                                            
                                            hormonal
                                        
                                        
                                         
                                    
                                        
                                            
                                            autoimmune
                                        
                                        
                                         
                                    
                                        
                                            
                                            hematologic
                                        
                                        
                                         
                                    
                                        
                                            
                                            metabolic
                                        
                                        
                                         
                                    
                                        
                                            
                                            neurologic
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:canOccurBefore
                                    
                                 | 
                                
                                    
                                        
                                            
                                            cancer diagnosis
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:cause
                                    
                                 | 
                                
                                    
                                        
                                            
                                            neurological symptoms
                                        
                                        
                                         
                                    
                                        
                                            
                                            dermatological symptoms
                                        
                                        
                                         
                                    
                                        
                                            
                                            endocrine symptoms
                                        
                                        
                                         
                                    
                                        
                                            
                                            hematological symptoms
                                        
                                        
                                         
                                    
                                        
                                            
                                            musculoskeletal symptoms
                                        
                                        
                                         
                                    
                                        
                                            
                                            rheumatological symptoms
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:causedBy
                                    
                                 | 
                                
                                    
                                        
                                            
                                            infection
                                        
                                        
                                         
                                    
                                        
                                            
                                            metastasis
                                        
                                        
                                         
                                    
                                        
                                            
                                            direct tumor invasion
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:commonIn
                                    
                                 | 
                                
                                    
                                        
                                            gptkb:leukemia
                                        
                                         
                                    
                                        
                                            gptkb:cancer
                                        
                                         
                                    
                                        
                                            gptkb:Small_Cell_Lung_Cancer
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:diagnosedBy
                                    
                                 | 
                                
                                    
                                        
                                            
                                            laboratory tests
                                        
                                        
                                         
                                    
                                        
                                            
                                            clinical evaluation
                                        
                                        
                                         
                                    
                                        
                                            
                                            imaging studies
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:example
                                    
                                 | 
                                
                                    
                                        
                                            gptkb:dermatomyositis
                                        
                                         
                                    
                                        
                                            gptkb:Lambert-Eaton_myasthenic_syndrome
                                        
                                         
                                    
                                        
                                            gptkb:hypercalcemia
                                        
                                         
                                    
                                        
                                            gptkb:Cushing_syndrome
                                        
                                         
                                    
                                        
                                            gptkb:SIADH
                                        
                                         
                                    
                                        
                                            gptkb:acanthosis_nigricans
                                        
                                         
                                    
                                        
                                            gptkb:migratory_thrombophlebitis
                                        
                                         
                                    
                                        
                                            gptkb:paraneoplastic_cerebellar_degeneration
                                        
                                         
                                    
                                        
                                            
                                            polycythemia
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:firstDescribed
                                    
                                 | 
                                
                                    
                                        
                                            
                                            1940s
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:mechanismOfAction
                                    
                                 | 
                                
                                    
                                        
                                            
                                            cytokine release
                                        
                                        
                                         
                                    
                                        
                                            
                                            ectopic hormone production
                                        
                                        
                                         
                                    
                                        
                                            
                                            immune cross-reactivity
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:occurredIn
                                    
                                 | 
                                
                                    
                                        
                                            gptkb:cancer
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:occursAfter
                                    
                                 | 
                                
                                    
                                        
                                            
                                            cancer diagnosis
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:treatment
                                    
                                 | 
                                
                                    
                                        
                                            
                                            immunosuppression
                                        
                                        
                                         
                                    
                                        
                                            
                                            symptomatic management
                                        
                                        
                                         
                                    
                                        
                                            
                                            treat underlying cancer
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:bfsParent
                                    
                                 | 
                                
                                    
                                        
                                            gptkb:neuroblastoma
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        gptkbp:bfsLayer
                                    
                                 | 
                                
                                    
                                        
                                            
                                            6
                                        
                                        
                                         
                                    
                                 | 
                            
                        
                            
                                | 
                                    
                                        https://www.w3.org/2000/01/rdf-schema#label
                                    
                                 | 
                                
                                    
                                        
                                            
                                            paraneoplastic syndromes
                                        
                                        
                                         
                                    
                                 |