Major Facilitator Superfamily (MFS)
GPTKB entity
Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
superfamily
|
| gptkbp:alsoKnownAs |
gptkb:MFS
|
| gptkbp:contains |
gptkb:lactose_permease
gptkb:multidrug_resistance_protein amino acid transporter drug:H+ antiporter monocarboxylate transporter nitrate transporter organic anion transporter phosphate transporter |
| gptkbp:database |
InterPro: IPR020846
PROSITE: PS50850 Pfam: PF07690 TCDB: 2.A.1 UniProtKB family: MFS |
| gptkbp:describedYear |
1993
|
| gptkbp:discoveredBy |
Henderson PJ
|
| gptkbp:evolvesFrom |
ancient
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:function |
solute transport
membrane transport small molecule transport |
| gptkbp:GO_term |
gptkb:GO:0005215
GO:0016021 GO:0015293 |
| https://www.w3.org/2000/01/rdf-schema#label |
Major Facilitator Superfamily (MFS)
|
| gptkbp:importantFor |
antibiotic resistance
cellular homeostasis waste export nutrient uptake drug efflux |
| gptkbp:mechanismOfAction |
facilitated diffusion
secondary active transport |
| gptkbp:memberOf |
transporter classification database
|
| gptkbp:relatedTo |
ABC transporter superfamily
MATE transporter superfamily RND transporter superfamily SMR transporter superfamily |
| gptkbp:structure |
12 transmembrane helices
|
| gptkbp:substrate |
drugs
ions sugars metabolites |
| gptkbp:TCDB_family |
2.A.1
|
| gptkbp:bfsParent |
gptkb:O15530
|
| gptkbp:bfsLayer |
7
|