Statements (46)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
breast cancer 1, early onset (mouse)
|
| gptkbp:associatedWith |
breast cancer susceptibility
|
| gptkbp:encodes |
BRCA1 protein (mouse)
|
| gptkbp:Entrez_Gene_ID |
12189
ENSMUSG00000017146 |
| gptkbp:expressedIn |
gptkb:testis
brain liver mammary gland |
| gptkbp:function |
DNA repair
tumor suppression |
| gptkbp:gene |
Brca1
|
| https://www.w3.org/2000/01/rdf-schema#label |
mouse Brca1
|
| gptkbp:interactsWith |
gptkb:CtIP
gptkb:BARD1 gptkb:PALB2 gptkb:p53 gptkb:RAD51 ATM |
| gptkbp:involves |
ubiquitination
cell cycle checkpoint homologous recombination transcriptional regulation |
| gptkbp:locatedOnChromosome |
mouse chromosome 11
|
| gptkbp:mutation_model |
Brca1 knockout mouse
conditional Brca1 mutant mouse |
| gptkbp:mutationAssociatedWith |
genomic instability
embryonic lethality defective DNA repair |
| gptkbp:organism |
gptkb:Mus_musculus
|
| gptkbp:orthologIn |
human BRCA1
|
| gptkbp:proteinFamily |
gptkb:BRCT_domain
RING finger domain |
| gptkbp:regulates |
apoptosis
cell proliferation gene expression DNA damage response chromatin remodeling |
| gptkbp:UniProtID |
Q61166
|
| gptkbp:used_in |
cancer research
genetic studies developmental biology studies DNA repair studies |
| gptkbp:bfsParent |
gptkb:HGNC:1097
|
| gptkbp:bfsLayer |
6
|