|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
no
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
neurodegenerative diseases
|
|
gptkbp:cofactor
|
gptkb:FAD
|
|
gptkbp:discoveredBy
|
gptkb:Mary_Bernheim
|
|
gptkbp:discoveredIn
|
1928
|
|
gptkbp:distinctFrom
|
gptkb:MAOA
|
|
gptkbp:EC_number
|
1.4.3.4
|
|
gptkbp:encodedBy
|
gptkb:MAOB_gene
|
|
gptkbp:EnzymeClass
|
oxidoreductase
|
|
gptkbp:expressedIn
|
brain
liver
platelets
|
|
gptkbp:foundIn
|
gptkb:human
other mammals
|
|
gptkbp:fullName
|
gptkb:Monoamine_oxidase_B
|
|
gptkbp:function
|
catalyzes the oxidative deamination of monoamines
|
|
gptkbp:gene
|
gptkb:MAOB_gene
gptkb:MAOB
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6833
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAOB
|
|
gptkbp:inhibitedBy
|
gptkb:rasagiline
gptkb:selegiline
gptkb:safinamide
increases dopamine levels
|
|
gptkbp:locatedOnChromosome
|
Xp11.3
|
|
gptkbp:location
|
outer mitochondrial membrane
|
|
gptkbp:molecularWeight
|
58 kDa
|
|
gptkbp:OMIM
|
309860
|
|
gptkbp:orthologIn
|
mouse Maob
rat Maob
|
|
gptkbp:PDB
|
gptkb:1GOS
|
|
gptkbp:proteinFamily
|
monoamine oxidase family
|
|
gptkbp:RefSeq
|
NM_000898
|
|
gptkbp:relatedTo
|
neurotransmitter metabolism
dopamine metabolism
benzylamine metabolism
phenylethylamine metabolism
|
|
gptkbp:significance
|
target for Parkinson's disease treatment
target for depression treatment
|
|
gptkbp:structure
|
flavin-containing enzyme
|
|
gptkbp:substrate
|
gptkb:benzylamine
dopamine
phenylethylamine
|
|
gptkbp:UniProtID
|
gptkb:P27338
|
|
gptkbp:bfsParent
|
gptkb:MAO-B
gptkb:monoamine_oxidase_B
|
|
gptkbp:bfsLayer
|
7
|