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gptkbp:instanceOf
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gptkb:protein
gptkb:enzyme
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gptkbp:alternativeName
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gptkb:RNASEN
gptkb:Ribonuclease_III_Drosha
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gptkbp:associatedWith
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miRNA biogenesis pathway
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gptkbp:biologicalProcess
|
ribonuclease III activity
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gptkbp:discoveredIn
|
2004
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gptkbp:EC_number
|
3.1.26.3
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gptkbp:encodedBy
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gptkb:DROSHA_gene
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gptkbp:formsComplexWith
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gptkb:DGCR8_protein
gptkb:Microprocessor_complex
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gptkbp:foundIn
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gptkb:Mus_musculus
gptkb:Homo_sapiens
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gptkbp:function
|
cleavage of primary microRNA (pri-miRNA)
microRNA processing
|
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gptkbp:locatedOnChromosome
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gptkb:chromosome_5_(human)
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gptkbp:location
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gptkb:nucleus
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gptkbp:mutationAssociatedWith
|
linked to cancer
linked to developmental disorders
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gptkbp:regulates
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gene expression
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gptkbp:requires
|
miRNA maturation
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gptkbp:species
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gptkb:Eukaryotes
|
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gptkbp:structure
|
contains double-stranded RNA-binding domain
contains two RNase III domains
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gptkbp:UniProtID
|
gptkb:Q9NRR4
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gptkbp:bfsParent
|
gptkb:microRNA_(miRNA)
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gptkbp:bfsLayer
|
9
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Drosha enzyme
|