gptkbp:instanceOf
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gptkb:protein
gptkb:enzyme
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gptkbp:alternativeName
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gptkb:RNASEN
gptkb:Ribonuclease_III_Drosha
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gptkbp:associatedWith
|
miRNA biogenesis pathway
|
gptkbp:biologicalProcess
|
ribonuclease III activity
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gptkbp:discoveredIn
|
2004
|
gptkbp:EC_number
|
3.1.26.3
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gptkbp:encodedBy
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gptkb:DROSHA_gene
|
gptkbp:formsComplexWith
|
gptkb:DGCR8_protein
gptkb:Microprocessor_complex
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
gptkbp:function
|
cleavage of primary microRNA (pri-miRNA)
microRNA processing
|
https://www.w3.org/2000/01/rdf-schema#label
|
Drosha enzyme
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5_(human)
|
gptkbp:location
|
gptkb:nucleus
|
gptkbp:mutationAssociatedWith
|
linked to cancer
linked to developmental disorders
|
gptkbp:regulates
|
gene expression
|
gptkbp:requires
|
miRNA maturation
|
gptkbp:species
|
gptkb:Eukaryotes
|
gptkbp:structure
|
contains double-stranded RNA-binding domain
contains two RNase III domains
|
gptkbp:UniProtID
|
gptkb:Q9NRR4
|
gptkbp:bfsParent
|
gptkb:non-coding_RNA
|
gptkbp:bfsLayer
|
6
|