Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:determines |
X-ray crystallography
cryo-electron microscopy |
| gptkbp:discoveredBy |
gptkb:Gregory_J._Hannon
|
| gptkbp:domain |
helicase domain
PAZ domain RNase III domain |
| gptkbp:EC_number |
3.1.26.3
|
| gptkbp:encodedBy |
gptkb:DICER1_gene
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
cleaves double-stranded RNA
produces microRNAs produces small interfering RNAs |
| https://www.w3.org/2000/01/rdf-schema#label |
Dicer enzyme
|
| gptkbp:involvedIn |
gptkb:RNA_interference
gene silencing |
| gptkbp:location |
gptkb:cytoplasm
|
| gptkbp:molecularWeight |
~200 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:DICER1_syndrome |
| gptkbp:orthologIn |
animals
fungi plants |
| gptkbp:product |
gptkb:miRNA
gptkb:siRNA |
| gptkbp:regulates |
gene expression
|
| gptkbp:requires |
microRNA maturation
siRNA maturation |
| gptkbp:substrate |
double-stranded RNA
pre-microRNA |
| gptkbp:bfsParent |
gptkb:RNA_interference
|
| gptkbp:bfsLayer |
5
|