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gptkbp:instanceOf
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non-coding RNA
biological molecule
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gptkbp:abbreviation
|
non-coding RNA
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gptkbp:biogenesis
|
processed by Dicer
processed by Drosha
transcribed from DNA
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gptkbp:component
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gptkb:RNA-induced_silencing_complex
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gptkbp:conservedIn
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evolution
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gptkbp:database
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gptkb:miRBase
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gptkbp:discoveredBy
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gptkb:Victor_Ambros
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gptkbp:discoveredIn
|
1993
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gptkbp:discoveredInOrganism
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gptkb:Caenorhabditis_elegans
|
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gptkbp:exportedTo
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gptkb:Exportin-5
|
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gptkbp:firstDescribed
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gptkb:lin-4_gene
gptkb:Gary_Ruvkun
gptkb:Victor_Ambros
1993
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gptkbp:foundIn
|
animals
plants
eukaryotes
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gptkbp:fullName
|
non-coding RNA
|
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gptkbp:function
|
gene regulation
post-transcriptional gene silencing
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|
https://www.w3.org/2000/01/rdf-schema#label
|
miRNA
|
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gptkbp:length
|
about 22 nucleotides
|
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gptkbp:mechanismOfAction
|
binds to mRNA
inhibits translation
promotes mRNA degradation
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gptkbp:numberOfKnownHumanmiRNAs
|
over 2000
|
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gptkbp:processor
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gptkb:Dicer
gptkb:Drosha
|
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gptkbp:regulates
|
gene expression
protein synthesis
mRNA stability
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gptkbp:relatedTo
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gptkb:siRNA
gptkb:piRNA
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gptkbp:role
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gptkb:cancer
apoptosis
cell differentiation
development
metabolism
immune response
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gptkbp:sequence
|
single-stranded RNA
|
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gptkbp:structure
|
hairpin precursor
|
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gptkbp:studiedIn
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genetics
molecular biology
bioinformatics
|
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gptkbp:therapeuticPotential
|
biomarker
drug target
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gptkbp:bfsParent
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gptkb:RNA_polymerase
gptkb:non-coding_RNA
gptkb:Dicer_enzyme
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gptkbp:bfsLayer
|
6
|