|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:RNASEN
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:cleavage
|
pri-miRNA to pre-miRNA
|
|
gptkbp:discoveredIn
|
2004
|
|
gptkbp:EC_number
|
3.1.26.3
|
|
gptkbp:encodedBy
|
gptkb:DROSHA_gene
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:formsComplexWith
|
gptkb:DGCR8
gptkb:Microprocessor_complex
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
ribonuclease
microRNA processing
|
|
gptkbp:GO_term
|
GO:0004519
|
|
gptkbp:inhibitedBy
|
viral proteins
|
|
gptkbp:interactsWith
|
gptkb:FUS_protein
gptkb:SMAD_proteins
p68 (DDX5)
p72 (DDX17)
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
chromosome 5p13.3
|
|
gptkbp:molecularWeight
|
~160 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Wilms_tumor
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
6V5B
|
|
gptkbp:phosphorylates
|
regulates activity
|
|
gptkbp:regulates
|
post-transcriptional gene silencing
|
|
gptkbp:requires
|
miRNA biogenesis
|
|
gptkbp:reviewedBy
|
gptkb:Nature
gptkb:science
gptkb:Cell
|
|
gptkbp:structure
|
contains double-stranded RNA-binding domain
contains RNase III domains
|
|
gptkbp:substrate
|
primary microRNA (pri-miRNA)
|
|
gptkbp:UniProtID
|
gptkb:Q9NRR4
|
|
gptkbp:bfsParent
|
gptkb:miRNA
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Drosha
|