|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alsoKnownAs
|
gptkb:IL-17A
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:IL17A_gene
|
|
gptkbp:Entrez_Gene_ID
|
3605
|
|
gptkbp:expressedIn
|
activated T cells
|
|
gptkbp:function
|
pro-inflammatory cytokine
recruits neutrophils
stimulates production of other cytokines
|
|
gptkbp:HGNC_ID
|
5981
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin-17A
|
|
gptkbp:involvedIn
|
asthma
multiple sclerosis
autoimmune diseases
psoriasis
rheumatoid arthritis
host defense against bacteria
host defense against fungi
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p12
|
|
gptkbp:memberOf
|
gptkb:interleukin-17_family
|
|
gptkbp:molecularWeight
|
~35 kDa
|
|
gptkbp:OMIM
|
603149
|
|
gptkbp:producedBy
|
gptkb:natural_killer_cells
gptkb:gamma_delta_T_cells
gptkb:Th17_cells
gptkb:innate_lymphoid_cells
|
|
gptkbp:promotion
|
production of IL-6
production of G-CSF
production of antimicrobial peptides
production of chemokines
|
|
gptkbp:recipient
|
gptkb:IL-17RA
gptkb:IL-17RC
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
gptkb:protein
homodimer
|
|
gptkbp:target
|
gptkb:secukinumab
gptkb:ixekizumab
|
|
gptkbp:UniProtID
|
gptkb:Q16552
|
|
gptkbp:bfsParent
|
gptkb:Cosentyx
|
|
gptkbp:bfsLayer
|
5
|