Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine family
|
| gptkbp:alternativeName |
IL-17 cytokine family
|
| gptkbp:composedOf |
gptkb:IL-17A
IL-17F IL-17E IL-17B IL-17C IL-17D |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:function |
pro-inflammatory cytokine activity
|
| https://www.w3.org/2000/01/rdf-schema#label |
interleukin-17 family
|
| gptkbp:involvedIn |
autoimmune diseases
host defense against pathogens |
| gptkbp:locatedOnChromosome |
chromosome 5 (IL-17B, IL-17C, IL-17D, IL-17E)
chromosome 6 (IL-17A and IL-17F) |
| gptkbp:producedBy |
T helper 17 cells
|
| gptkbp:recipient |
IL-17 receptor family
|
| gptkbp:relatedTo |
psoriasis
rheumatoid arthritis inflammatory bowel disease |
| gptkbp:target |
biologic drugs (e.g., secukinumab, ixekizumab)
|
| gptkbp:bfsParent |
gptkb:interleukin-17A
|
| gptkbp:bfsLayer |
6
|