|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:GON-10
gptkb:HD1
gptkb:RPD3
histone deacetylase RPD3 homolog
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
cardiovascular diseases
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:Entrez_Gene_ID
|
3065
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.5.1.98
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_1
|
|
gptkbp:function
|
regulation of gene expression
catalyzes the removal of acetyl groups from lysine residues on histone proteins
|
|
gptkbp:gene
|
gptkb:HDAC1
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human HDAC1
|
|
gptkbp:inhibitedBy
|
gptkb:Valproic_acid
gptkb:Vorinostat
Trichostatin A
Entinostat
Romidepsin
|
|
gptkbp:interactsWith
|
gptkb:HDAC2
gptkb:SAP30
gptkb:RB1
gptkb:CoREST
gptkb:SIN3A
gptkb:YY1
MTA2
MTA1
|
|
gptkbp:involves
|
apoptosis
DNA repair
cell cycle regulation
transcriptional repression
chromatin remodeling
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p35.2
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
4BKX
5ICN
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:class_I_HDAC
histone deacetylase family
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
Q13547
|
|
gptkbp:bfsParent
|
gptkb:CLR-3
|
|
gptkbp:bfsLayer
|
7
|