hematopoietic protein tyrosine phosphatase
GPTKB entity
Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:PTPN6
gptkb:SHP-1 |
| gptkbp:encodedBy |
PTPN6 gene
|
| gptkbp:enzymeClassification |
EC 3.1.3.48
|
| gptkbp:expressedIn |
hematopoietic cells
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
protein tyrosine phosphatase activity
negative regulation of cell signaling |
| https://www.w3.org/2000/01/rdf-schema#label |
hematopoietic protein tyrosine phosphatase
|
| gptkbp:involvedIn |
signal transduction
immune response |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_12q24
|
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
68 kDa
|
| gptkbp:mutationAssociatedWith |
leukemia
autoimmune diseases |
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Rattus_norvegicus |
| gptkbp:regulates |
gptkb:JAK/STAT_signaling_pathway
B cell receptor signaling T cell receptor signaling |
| gptkbp:structure |
contains SH2 domains
contains PTP domain |
| gptkbp:UniProtID |
gptkb:P29350
|
| gptkbp:bfsParent |
gptkb:PTPN7
|
| gptkbp:bfsLayer |
7
|