Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeSiteResidue |
tyrosine residue
|
| gptkbp:alsoKnownAs |
COX enzymes
|
| gptkbp:catalyzes |
conversion of arachidonic acid to prostaglandin H2
|
| gptkbp:COX-1 |
constitutively expressed
involved in gastric mucosa protection |
| gptkbp:COX-2 |
inducible
involved in pain and inflammation upregulated during inflammation |
| gptkbp:COX-3 |
less well understood
may be involved in fever response |
| gptkbp:discoveredBy |
gptkb:John_Vane
|
| gptkbp:EC_number |
1.14.99.1
|
| gptkbp:encodedBy |
gptkb:PTGS2_gene
PTGS1 gene |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:foundIn |
mammals
|
| gptkbp:function |
mediate fever
mediate inflammation mediate pain |
| gptkbp:haveIsoform |
gptkb:COX-2
gptkb:COX-1 COX-3 |
| https://www.w3.org/2000/01/rdf-schema#label |
cyclooxygenase enzymes
|
| gptkbp:inhibitedBy |
nonsteroidal anti-inflammatory drugs
reduces prostaglandin synthesis can cause gastrointestinal side effects can reduce fever can reduce inflammation can reduce pain can increase risk of cardiovascular events (COX-2 inhibitors) |
| gptkbp:involvedIn |
prostaglandin biosynthesis
|
| gptkbp:presentIn |
gptkb:skeletal_muscle
brain lungs liver kidneys reproductive organs stomach intestines platelets endothelial cells |
| gptkbp:structure |
homodimer
|
| gptkbp:target |
gptkb:ibuprofen
gptkb:naproxen gptkb:aspirin gptkb:celecoxib |
| gptkbp:bfsParent |
gptkb:arachidonic_acid
|
| gptkbp:bfsLayer |
7
|