Thrombin

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy factor V
factor VIII
factor XIII
protein C
protein S
thrombomodulin
gptkbp:alternativeName gptkb:coagulation_factor_IIa
gptkb:serine_protease_1
factor IIa
gptkbp:associatedWith hemophilia
thrombosis
disseminated intravascular coagulation
gptkbp:CASNumber 9002-04-4
gptkbp:catalyzes conversion of fibrinogen to fibrin
gptkbp:cofactor phospholipids
calcium ions
gptkbp:discoveredBy gptkb:Paul_Morawitz
gptkbp:discoveredIn 1905
gptkbp:EC_number 3.4.21.5
gptkbp:expressedIn blood
liver
gptkbp:foundIn gptkb:plasma
gptkbp:function gptkb:serine_protease
blood coagulation
gptkbp:gene gptkb:F2
https://www.w3.org/2000/01/rdf-schema#label Thrombin
gptkbp:inhibitedBy gptkb:antithrombin
gptkb:heparin
hirudin
gptkbp:medicalUse surgical procedures
diagnostic reagent
topical hemostatic agent
gptkbp:molecularWeight 36 kDa
gptkbp:PDB 1PPB
gptkbp:predecessor prothrombin
gptkbp:producedBy prothrombinase complex
gptkbp:role wound healing
inflammation
platelet activation
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure two polypeptide chains
gptkbp:substrate gptkb:fibrinogen
protease-activated receptors
gptkbp:UniProtID P00734
gptkbp:used_in fibrin sealants
laboratory coagulation tests
gptkbp:bfsParent gptkb:Platelet
gptkbp:bfsLayer 5