class I phosphoinositide 3-kinase

URI: https://gptkb.org/entity/class_I_phosphoinositide_3-kinase
GPTKB entity
Statements (31)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
gptkbp:catalyzes phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2)
gptkbp:discoveredIn 1990s
gptkbp:EC_number 2.7.1.153
gptkbp:foundIn eukaryotic cells
gptkbp:gene gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:PIK3CG
https://www.w3.org/2000/01/rdf-schema#label class I phosphoinositide 3-kinase
gptkbp:inhibitedBy gptkb:LY294002
gptkb:wortmannin
gptkbp:involvedIn cell proliferation
cell survival
metabolism
cell growth
cell migration
gptkbp:involves gptkb:cancer
gptkb:diabetes
inflammatory diseases
gptkbp:product gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
gptkbp:relatedTo gptkb:PI3K/AKT/mTOR_pathway
gptkbp:subspecies class IA phosphoinositide 3-kinase
class IB phosphoinositide 3-kinase
gptkbp:subunit p110 catalytic subunit
regulatory subunit (p85, p55, or p50)
gptkbp:bfsParent gptkb:catalytic_subunit_of_class_I_PI3K
gptkbp:bfsLayer 6