|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CD195
CKR-5
chemokine (C-C motif) receptor 5
|
|
gptkbp:binds
|
CCL3
CCL4
CCL5
MIP-1α
MIP-1β
RANTES
|
|
gptkbp:CCR5-Δ32Consequence
|
HIV resistance
|
|
gptkbp:CCR5-Δ32Frequency
|
higher in European populations
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodedBy
|
CCR5 gene
|
|
gptkbp:Entrez_Gene_ID
|
1234
ENSG00000160791
|
|
gptkbp:expressedIn
|
gptkb:T_cells
gptkb:microglia
dendritic cells
macrophages
|
|
gptkbp:fullName
|
C-C chemokine receptor type 5
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
chemokine receptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1606
|
|
gptkbp:HIVCoreceptor
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CCR5
|
|
gptkbp:length
|
352 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3p21.31
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
40 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:CCR5-Δ32
|
|
gptkbp:OMIM
|
601373
|
|
gptkbp:orthologInMouse
|
Ccr5
|
|
gptkbp:PDB
|
4MBS
|
|
gptkbp:proteinFamily
|
gptkb:G_protein-coupled_receptor
chemokine receptor family
|
|
gptkbp:regulates
|
inflammatory response
immune cell trafficking
|
|
gptkbp:role
|
HIV infection
inflammatory diseases
West Nile virus infection
|
|
gptkbp:targetOfDrug
|
aplaviroc
leronlimab
maraviroc
vicriviroc
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:UniProtID
|
P51681
|
|
gptkbp:bfsParent
|
gptkb:chromosome_3
gptkb:HIV-1
gptkb:Human_Immunodeficiency_Virus
|
|
gptkbp:bfsLayer
|
6
|