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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:PIK3C3
|
|
gptkbp:biologicalProcess
|
kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:lysosome
gptkb:endosome
gptkb:cytoplasm
|
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gptkbp:discoveredIn
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gptkb:Saccharomyces_cerevisiae
|
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gptkbp:encodedBy
|
gptkb:PIK3C3_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.1.137
|
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gptkbp:formsComplexWith
|
gptkb:Beclin-1
gptkb:ATG14L
gptkb:UVRAG
gptkb:Vps15
|
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gptkbp:function
|
phosphatidylinositol 3-kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
catalytic subunit Vps34
|
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gptkbp:inhibitedBy
|
gptkb:3-methyladenine
gptkb:Wortmannin
|
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gptkbp:involvedIn
|
autophagy
endocytosis
|
|
gptkbp:length
|
887
|
|
gptkbp:locatedOnChromosome
|
18q12.3
|
|
gptkbp:molecularWeight
|
101 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurodegeneration
metabolic disorders
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
gptkb:Arabidopsis_thaliana
|
|
gptkbp:phosphorylates
|
phosphatidylinositol
|
|
gptkbp:product
|
phosphatidylinositol 3-phosphate
|
|
gptkbp:regulates
|
autophagosome formation
lysosomal function
membrane trafficking
vesicle-mediated transport
endosomal sorting
mTOR signaling
|
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gptkbp:requires
|
cell survival
autophagy initiation
|
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gptkbp:species
|
gptkb:human
gptkb:mouse
gptkb:yeast
|
|
gptkbp:structure
|
contains C2 domain
contains kinase domain
contains PI3K/PI4K domain
contains helical domain
|
|
gptkbp:UniProtID
|
gptkb:Q8NEB9
|
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gptkbp:bfsParent
|
gptkb:Class_III_PI3K
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gptkbp:bfsLayer
|
5
|