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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:activity
|
constitutively active
|
|
gptkbp:alsoKnownAs
|
gptkb:CK2
|
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gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:discoveredBy
|
1960s
|
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gptkbp:EC_number
|
2.7.11.1
|
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gptkbp:encodedBy
|
CSNK2A1
CSNK2A2
CSNK2B
|
|
gptkbp:family
|
CK2 family
|
|
gptkbp:function
|
phosphorylation of serine/threonine residues
|
|
gptkbp:GO_term
|
GO:0004674 (protein serine/threonine kinase activity)
|
|
gptkbp:inhibitedBy
|
CX-4945
TBB (4,5,6,7-tetrabromobenzotriazole)
|
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gptkbp:involvedIn
|
apoptosis
DNA repair
cell cycle regulation
transcription regulation
|
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gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:phosphorylation_site_preference
|
acidic residues near phosphorylation site
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:substrate
|
gptkb:casein
gptkb:NF-kB
gptkb:c-Myc
gptkb:p53
|
|
gptkbp:subunit
|
alpha subunit
beta subunit
alpha' subunit
|
|
gptkbp:UniProtID
|
P19784 (beta subunit)
P68400 (alpha subunit)
|
|
gptkbp:bfsParent
|
gptkb:PI3K_inhibitor_LY294002
|
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gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
casein kinase 2
|