anti-apoptotic Bcl-2 proteins
GPTKB entity
Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
BH3-only proteins
pro-apoptotic Bcl-2 proteins |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:domain |
BH1 domain
BH2 domain BH3 domain BH4 domain |
| gptkbp:example |
gptkb:Bcl-2
gptkb:Bcl-xL gptkb:Bcl-w gptkb:Mcl-1 A1/Bfl-1 |
| gptkbp:function |
inhibit apoptosis
|
| https://www.w3.org/2000/01/rdf-schema#label |
anti-apoptotic Bcl-2 proteins
|
| gptkbp:involvedIn |
cancer cell survival
|
| gptkbp:locale |
gptkb:endoplasmic_reticulum
nuclear envelope mitochondrial outer membrane |
| gptkbp:memberOf |
gptkb:Bcl-2_protein_family
|
| gptkbp:proteinFamily |
BCL2 gene family
|
| gptkbp:regulates |
caspase activation
cytochrome c release mitochondrial outer membrane permeabilization |
| gptkbp:target |
gptkb:BH3_mimetics
anticancer drugs |
| gptkbp:bfsParent |
gptkb:NOXA
|
| gptkbp:bfsLayer |
7
|