ramipril

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:drug
ACE inhibitor
gptkbp:approvalYear 1991
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode C09AA05
gptkbp:availableOn gptkb:tablet
capsule
gptkbp:bioavailability 28%
gptkbp:brand gptkb:Altace
gptkb:Tritace
Ramace
gptkbp:CASNumber 87333-19-5
gptkbp:category prodrug
antihypertensive agent
World Health Organization essential medicine
gptkbp:chemicalFormula C23H32N2O5
gptkbp:contraindication pregnancy
bilateral renal artery stenosis
history of angioedema
gptkbp:discoveredBy gptkb:Hoechst_AG
gptkbp:discoveredIn 1981
gptkbp:eliminationHalfLife 13-17 hours
gptkbp:excretion urine
feces
gptkbp:firstPassMetabolism yes
https://www.w3.org/2000/01/rdf-schema#label ramipril
gptkbp:interactsWith gptkb:NSAIDs
gptkb:aliskiren
lithium
potassium-sparing diuretics
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits angiotensin-converting enzyme
gptkbp:metabolism gptkb:ramiprilat
gptkbp:patent 1981
gptkbp:pregnancyCategory D (US)
gptkbp:proteinBinding 73%
gptkbp:riskFactor renal impairment
teratogenicity
gptkbp:routeOfAdministration oral
gptkbp:sideEffect cough
hypotension
hyperkalemia
angioedema
gptkbp:usedFor heart failure
hypertension
prevention of cardiovascular events
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:C09AA07
gptkb:Altace
gptkbp:bfsLayer 6