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acute promyelocytic leukemia
URI:
https://gptkb.org/entity/acute_promyelocytic_leukemia
GPTKB entity
Statements (50)
Predicate
Object
gptkbp:instanceOf
gptkb:disease
leukemia
gptkbp:abbreviation
gptkb:APL
gptkbp:affects
adults
children
gptkbp:causedBy
gptkb:PML-RARA_fusion_gene
gptkb:t(15;17)(q24;q21)_translocation
gptkbp:complication
disseminated intravascular coagulation
gptkbp:containsGene
gptkb:RARA
gptkb:PML
gptkbp:diagnosedBy
bone marrow biopsy
cytogenetic analysis
molecular testing
gptkbp:firstDescribed
gptkb:Hillestad
1957
gptkbp:hasEpidemiology
accounts for 5-10% of AML cases
rare leukemia
gptkbp:hasOrphanetID
gptkb:ORPHA:99360
gptkbp:hasRelapseRate
low with modern therapy
gptkbp:hasStandardOfCare
gptkb:ATRA_plus_arsenic_trioxide
gptkb:ATRA_plus_chemotherapy
gptkbp:hasTreatmentResponse
high remission rate
gptkbp:hasType
promyelocyte
https://www.w3.org/2000/01/rdf-schema#label
acute promyelocytic leukemia
gptkbp:ICD-10_code
gptkb:C92.4
gptkbp:marking
gptkb:CD13
gptkb:HLA-DR_negative
gptkb:MPO
gptkb:CD33
gptkbp:MeSH_ID
gptkb:D015470
gptkbp:mortalityRate
high without treatment
low with treatment
gptkbp:OMIM
612376
gptkbp:prognosis
good with treatment
gptkbp:riskFactor
radiation exposure
genetic disorder
previous chemotherapy
gptkbp:subclassOf
gptkb:acute_myeloid_leukemia
gptkbp:symptom
gptkb:anemia
bleeding
fatigue
infections
bruising
gptkbp:synonym
gptkb:M3_AML
gptkb:APL
gptkbp:treatment
gptkb:all-trans_retinoic_acid
gptkb:arsenic_trioxide
chemotherapy
gptkbp:bfsParent
gptkb:acute_myeloid_leukemia
gptkbp:bfsLayer
5