acute promyelocytic leukemia

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:leukemia gptkb:disease
gptkbp:abbreviation	gptkb:APL
gptkbp:affects	adults children
gptkbp:causedBy	gptkb:PML-RARA_fusion_gene gptkb:t(15;17)(q24;q21)_translocation
gptkbp:complication	disseminated intravascular coagulation
gptkbp:containsGene	gptkb:RARA gptkb:PML
gptkbp:diagnosedBy	bone marrow biopsy cytogenetic analysis molecular testing
gptkbp:firstDescribed	gptkb:Hillestad 1957
gptkbp:hasEpidemiology	accounts for 5-10% of AML cases rare leukemia
gptkbp:hasOrphanetID	gptkb:ORPHA:99360
gptkbp:hasRelapseRate	low with modern therapy
gptkbp:hasStandardOfCare	gptkb:ATRA_plus_arsenic_trioxide gptkb:ATRA_plus_chemotherapy
gptkbp:hasTreatmentResponse	high remission rate
gptkbp:hasType	promyelocyte
gptkbp:ICD-10_code	gptkb:C92.4
gptkbp:marking	gptkb:CD13 gptkb:HLA-DR_negative gptkb:MPO gptkb:CD33
gptkbp:MeSH_ID	gptkb:D015470
gptkbp:mortalityRate	high without treatment low with treatment
gptkbp:OMIM	612376
gptkbp:prognosis	good with treatment
gptkbp:riskFactor	gptkb:genetic_disorder radiation exposure previous chemotherapy
gptkbp:subclassOf	gptkb:acute_myeloid_leukemia
gptkbp:symptom	gptkb:anemia bleeding fatigue infections bruising
gptkbp:synonym	gptkb:M3_AML gptkb:APL
gptkbp:treatment	gptkb:all-trans_retinoic_acid gptkb:arsenic_trioxide chemotherapy
gptkbp:bfsParent	gptkb:acute_myeloid_leukemia
gptkbp:bfsLayer	5
https://www.w3.org/2000/01/rdf-schema#label	acute promyelocytic leukemia