|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:associatedWith
|
inflammation
immune response
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:deficiencyCauses
|
myeloperoxidase deficiency
|
|
gptkbp:EC_number
|
1.11.2.2
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
gptkb:placenta
gptkb:testis
gptkb:thymus
blood
liver
lymph nodes
spleen
bone marrow
pancreas
monocytes
azurophilic granules
|
|
gptkbp:foundIn
|
neutrophil granulocytes
|
|
gptkbp:fullName
|
gptkb:Myeloperoxidase
|
|
gptkbp:function
|
produces hypochlorous acid from hydrogen peroxide and chloride anion
|
|
gptkbp:gene
|
gptkb:MPO_gene
|
|
gptkbp:HGNC_ID
|
7198
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MPO
|
|
gptkbp:inhibitedBy
|
gptkb:4-aminobenzoic_acid_hydrazide
azide
cyanide
|
|
gptkbp:locatedOnChromosome
|
17q23.1
|
|
gptkbp:molecularWeight
|
~150 kDa
|
|
gptkbp:OMIM
|
606989
|
|
gptkbp:orthologIn
|
gptkb:MPO
|
|
gptkbp:orthologInMouse
|
gptkb:Mpo
|
|
gptkbp:PDB
|
gptkb:1CXP
|
|
gptkbp:product
|
chloramines
hypochlorous acid
singlet oxygen
|
|
gptkbp:relatedTo
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:cardiovascular_disease
multiple sclerosis
atherosclerosis
rheumatoid arthritis
|
|
gptkbp:structure
|
dimeric protein
|
|
gptkbp:substrate
|
hydrogen peroxide
chloride anion
|
|
gptkbp:UniProtID
|
P05164
|
|
gptkbp:usedAs
|
biomarker
|
|
gptkbp:usedIn
|
diagnosis of myeloid lineage in leukemia
|
|
gptkbp:bfsParent
|
gptkb:BepiColombo_mission
|
|
gptkbp:bfsLayer
|
4
|