Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
gptkb:vitamin_A vitamin A derivative |
| gptkbp:administeredBy |
oral medication
topical medication |
| gptkbp:affects |
cell differentiation
cell proliferation gene expression |
| gptkbp:approvedBy |
gptkb:United_States
1995 |
| gptkbp:ATCCode |
D10AD01
|
| gptkbp:CASNumber |
302-79-4
|
| gptkbp:category |
antineoplastic agent
dermatological preparation vitamin A analog |
| gptkbp:chemicalFormula |
C20H28O2
|
| gptkbp:combines |
gptkb:arsenic_trioxide
chemotherapy |
| gptkbp:contraindication |
pregnancy
|
| gptkbp:discoveredBy |
1950s
|
| gptkbp:foundIn |
animal sources as a metabolite of vitamin A
|
| https://www.w3.org/2000/01/rdf-schema#label |
all-trans retinoic acid
|
| gptkbp:IUPACName |
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
|
| gptkbp:KEGGID |
D00137
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
binds to retinoic acid receptors (RARs)
|
| gptkbp:meltingPoint |
180–182 °C
|
| gptkbp:MeSH_ID |
D014024
|
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
300.44 g/mol
|
| gptkbp:origin |
synthetic
|
| gptkbp:otherName |
gptkb:ATRA
gptkb:tretinoin |
| gptkbp:PubChem_CID |
CHEMBL1204
444795 DB00755 |
| gptkbp:regulates |
gptkb:FDA
|
| gptkbp:routeOfAdministration |
oral
topical |
| gptkbp:sideEffect |
headache
skin irritation bone pain teratogenicity dry skin |
| gptkbp:solubility |
insoluble in water
soluble in organic solvents |
| gptkbp:UNII |
5688UTC01R
|
| gptkbp:usedFor |
topical treatment of acne
treatment of acute promyelocytic leukemia |
| gptkbp:bfsParent |
gptkb:acute_promyelocytic_leukemia
|
| gptkbp:bfsLayer |
6
|