Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:healthcare_organization
|
| gptkbp:affects |
affects cell adhesion properties
influences neuronal differentiation inhibits growth of cancer cells modulates cell signaling pathways promotes differentiation of cells promotes differentiation of immature cells |
| gptkbp:antagonist |
inhibits proliferation of certain cancer cells
|
| gptkbp:application |
used in cancer therapy
|
| gptkbp:category |
vitamin A derivative
|
| gptkbp:cause_of_death |
induces apoptosis in certain cell types
|
| gptkbp:class |
carboxylic acid
|
| gptkbp:clinical_trial |
undergoing trials for various cancers
used in combination with chemotherapy |
| gptkbp:combatants |
high affinity for RA Rs
|
| gptkbp:composed_of |
synthesis from retinaldehyde
|
| gptkbp:developed_by |
vitamin A
|
| gptkbp:discovered_by |
1970s
|
| gptkbp:dissolved |
soluble in organic solvents
|
| gptkbp:ecological_role |
regulates gene expression
|
| gptkbp:financial_performance |
unstable in light
|
| gptkbp:has_skin |
improves skin texture and tone
|
| gptkbp:historical_source |
found in animal liver and fish oil
|
| https://www.w3.org/2000/01/rdf-schema#label |
all-trans retinoic acid
|
| gptkbp:ingredients |
C20 H28 O2
|
| gptkbp:interacts_with |
interacts with nuclear receptors
|
| gptkbp:is_a_source_of |
can be synthesized from beta-carotene
source of retinoic acid signaling |
| gptkbp:is_affected_by |
regulates cell cycle progression
affects tissue regeneration can stimulate or inhibit cell proliferation influences transcription of target genes modulates immune responses modulates inflammatory responses promotes stem cell differentiation |
| gptkbp:iso639-3 |
isomer of 13-cis retinoic acid
|
| gptkbp:lifespan |
can promote or inhibit cell survival depending on context
|
| gptkbp:manager |
administered orally or topically
|
| gptkbp:mass |
300.44 g/mol
|
| gptkbp:metabolism |
metabolized by cytochrome P450 enzymes
regulates metabolic processes |
| gptkbp:migration |
influences cell migration patterns
|
| gptkbp:pharmacokinetics |
absorbed in the gastrointestinal tract
may interact with anticoagulants acts as a signaling molecule |
| gptkbp:previous_name |
(2 E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
|
| gptkbp:promoter |
enhances transcription of specific genes
|
| gptkbp:provides_information_on |
included in treatment guidelines for APL
|
| gptkbp:regulates |
regulates expression of oncogenes
|
| gptkbp:regulatory_compliance |
approved for medical use in several countries
|
| gptkbp:reproduction |
critical for embryonic development
|
| gptkbp:research |
shown to induce apoptosis in cancer cells
|
| gptkbp:research_areas |
studied in developmental biology
used in dermatology for acne treatment |
| gptkbp:role |
treatment for acute promyelocytic leukemia
|
| gptkbp:safety_features |
generally well tolerated
|
| gptkbp:side_effect |
can cause skin irritation
affects bone metabolism influences hormone signaling may cause headache and nausea used in cancer treatment protocols |
| gptkbp:social_structure |
contains a conjugated double bond system
|
| gptkbp:storage |
store in a cool, dark place
|
| gptkbp:targets |
retinoic acid receptors (RA Rs)
|
| gptkbp:visual_effects |
important for vision development
|
| gptkbp:was_a_response_to |
reacts with nucleophiles
|
| gptkbp:bfsParent |
gptkb:RAR_(Retinoic_Acid_Receptor)
|
| gptkbp:bfsLayer |
6
|