|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:vitamin_A_derivative
gptkb:vitamin_A
|
|
gptkbp:administeredBy
|
gptkb:topical_medication
oral medication
|
|
gptkbp:affects
|
cell differentiation
cell proliferation
gene expression
|
|
gptkbp:approvedBy
|
gptkb:United_States
1995
|
|
gptkbp:ATCCode
|
D10AD01
|
|
gptkbp:CASNumber
|
302-79-4
|
|
gptkbp:category
|
gptkb:antineoplastic_agent
dermatological preparation
vitamin A analog
|
|
gptkbp:chemicalFormula
|
C20H28O2
|
|
gptkbp:combines
|
gptkb:arsenic_trioxide
chemotherapy
|
|
gptkbp:contraindication
|
pregnancy
|
|
gptkbp:discoveredBy
|
1950s
|
|
gptkbp:foundIn
|
animal sources as a metabolite of vitamin A
|
|
gptkbp:IUPACName
|
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
|
|
gptkbp:KEGGID
|
D00137
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
binds to retinoic acid receptors (RARs)
|
|
gptkbp:meltingPoint
|
180–182 °C
|
|
gptkbp:MeSH_ID
|
D014024
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
300.44 g/mol
|
|
gptkbp:origin
|
synthetic
|
|
gptkbp:otherName
|
gptkb:ATRA
gptkb:tretinoin
|
|
gptkbp:PubChem_CID
|
CHEMBL1204
444795
DB00755
|
|
gptkbp:regulates
|
gptkb:FDA
|
|
gptkbp:routeOfAdministration
|
oral
topical
|
|
gptkbp:sideEffect
|
headache
skin irritation
bone pain
teratogenicity
dry skin
|
|
gptkbp:solubility
|
insoluble in water
soluble in organic solvents
|
|
gptkbp:UNII
|
5688UTC01R
|
|
gptkbp:usedFor
|
topical treatment of acne
treatment of acute promyelocytic leukemia
|
|
gptkbp:bfsParent
|
gptkb:acute_promyelocytic_leukemia
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
all-trans retinoic acid
|