acetyl-CoA carboxylase alpha

URI: https://gptkb.org/entity/acetyl-CoA_carboxylase_alpha
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:ACAC
gptkb:ACC1
gptkbp:associatedWith gptkb:type_2_diabetes
gptkb:metabolic_syndrome
obesity
gptkbp:cofactor gptkb:biotin
gptkbp:discoveredIn 1960s
gptkbp:EC_number 6.4.1.2
gptkbp:encodedBy ACACA gene
gptkbp:family biotin-dependent carboxylases
gptkbp:function catalyzes carboxylation of acetyl-CoA to malonyl-CoA
gptkbp:gene gptkb:ACACA
gptkbp:GO_term GO:0003989
https://www.w3.org/2000/01/rdf-schema#label acetyl-CoA carboxylase alpha
gptkbp:inhibitedBy TOFA
soraphen A
CP-640186
gptkbp:locatedOnChromosome chromosome 17q12
gptkbp:location cytosol
gptkbp:molecularWeight 265 kDa
gptkbp:OMIM 200350
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn mouse Acaca
rat Acaca
zebrafish acaca
gptkbp:pathway fatty acid biosynthesis
gptkbp:PDB 2Y7Y
gptkbp:phosphorylates Ser218
Ser1200
Ser1215
Ser1263
Ser79
gptkbp:product gptkb:malonyl-CoA
gptkbp:regulates allosteric regulation by citrate
dephosphorylation by protein phosphatase 2A
inhibition by palmitoyl-CoA
phosphorylation by AMPK
gptkbp:significance target for anti-obesity drugs
target for type 2 diabetes drugs
gptkbp:structure homodimer
gptkbp:substrate acetyl-CoA
gptkbp:subunit homodimer
gptkbp:tissue_specificity liver
adipose tissue
mammary gland
gptkbp:UniProtID gptkb:Q13085
gptkbp:bfsParent gptkb:ACACA
gptkbp:bfsLayer 7